The Human Lysosome Gene Database

The Lysosome Gene Database is an ongoing effort to catalogue genes encoding lysosomal proteins. For each lysosomal gene, LGDB provides information on :

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View only genes reported lysosomal by of the following sources:

Proteomics Studies (view) - (select all | none)

 A gene network regulating lysosomal biogenesis and function.
Sardiello M, Science 2009 PubMed

 The human urine mannose 6-phosphate glycoproteome.
Sleat DE, Biochim Biophys Acta 2007 PubMed

 Integral and associated lysosomal membrane proteins.
Schröder B, Traffic 2007 PubMed

 Identification and validation of mannose 6-phosphate glycoproteins in human plasma reveal a wide range of lysosomal and non-lysosomal proteins.
Sleat DE, Mol Cell Proteomics 2006 PubMed

 Identification of sites of mannose 6-phosphorylation on lysosomal proteins.
Sleat DE, Mol Cell Proteomics 2006 PubMed

 The human brain mannose 6-phosphate glycoproteome: a complex mixture composed of multiple isoforms of many soluble lysosomal proteins.
Sleat DE, Proteomics 2005 PubMed

 Proteomic analysis of human lysosomes: application to monocytic and breast cancer cells.
Journet A, Proteomics 2002 PubMed

 Towards a human repertoire of monocytic lysosomal proteins.
Journet A, Electrophoresis 2000 PubMed

 Two-dimensional mapping and microsequencing of lysosomal proteins from human placenta.
Chataway TK, Placenta 1998 PubMed

Databases (view) - (select all | none)

 Reactome: a knowledge base of biologic pathways and processes.
Vastrik I, Genome Biol 2007 PubMed

 UniProt archive.
Leinonen R, Bioinformatics 2004 PubMed

 KEGG: kyoto encyclopedia of genes and genomes.
Kanehisa M, Nucleic Acids Res 2000 PubMed

 Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.
Ashburner M, Nat Genet 2000 PubMed

Literature Reviews (view) - (select all | none)

 The proteome of lysosomes.
Schröder BA, Proteomics 2010 PubMed

 Proteomics of the lysosome.
Lübke T, Biochim Biophys Acta 2009 PubMed

Systems Biology Approaches (view) - (select all | none)

 Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.
Palmieri M, Hum Mol Genet 2011 PubMed

Filter by HGNC gene symbol:

TFEB binding sitebp upstream TSS
(max ±2kb)bp downstream TSS

CLEAR motif bp upstream TSS
(max ±2kb)bp downstream TSS

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* exp. verified targets


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